Aimed at head-on interception situation of kinetic kill vehicle, the possibility of penetration using aerodynamics for hypersonic slide vehicle is analyzed, and the penetration guidance law is deduced perspective from maneuver interception scale escape according to the parameters at boost separating time of kinetic kill vehicle. Simulation result shows that the guidance law takes effect to escape maneuver interception scale while there is deviation between real initial interception condition and realistic interception condition.